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Familial localized scleroderma with paediatric onset: a review
Ida Yurtsever1, Małgorzata Łukomska1, Piotr Sobolewski2
1Department of Dermatology, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.
Postepy Dermatologii I Alergologii
|February 8, 2023
Summary
Familial localized scleroderma, a rare inflammatory skin condition, suggests a genetic component. This review examines literature and presents three pediatric cases, highlighting the need for further research into its hereditary nature.
Area of Science:
- Dermatology
- Genetics
- Immunology
Background:
- Localized scleroderma is an inflammatory skin disease with unclear etiology and pathogenesis.
- Genetic factors are suspected, but the interplay between genetics and environment is not well understood.
- Familial clustering suggests a hereditary component, though familial cases are rarely reported.
Purpose of the Study:
- To review the existing literature on familial localized scleroderma.
- To present three additional cases of familial localized scleroderma with pediatric onset.
- To contribute to understanding the genetic basis of localized scleroderma.
Main Methods:
- Literature review on familial localized scleroderma.
- Case series presentation of three pediatric patients with familial localized scleroderma.
Main Results:
- Familial localized scleroderma is infrequently documented.
- The presented cases add to the limited data on familial occurrence, particularly in pediatric populations.
Conclusions:
- Familial localized scleroderma warrants further investigation due to its potential genetic underpinnings.
- Understanding familial cases may elucidate the pathogenesis of localized scleroderma.
- More research is needed to clarify the role of genetics versus environmental factors.
