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Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
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Does HSP90 play an important role in psoriasis?
Rafał Czajkowski1, Sebastian Kaszewski2, Tadeusz Tadrowski1
1Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatologii I Alergologii
|February 8, 2023
Summary
Heat shock protein 90 (HSP90) mRNA expression is elevated in psoriasis patients, correlating with disease exacerbations. Factors like infections and stress significantly increase HSP90 levels, impacting psoriasis pathogenesis.
Area of Science:
- Dermatology
- Immunology
- Molecular Biology
Background:
- Psoriasis is a chronic inflammatory skin condition influenced by genetic and environmental factors.
- Heat shock protein 90 (HSP90) is implicated as an interleukin-17 (IL-17) receptor crucial in psoriasis pathogenesis.
Purpose of the Study:
- To investigate HSP90 gene expression in psoriatic keratinocytes.
- To analyze HSP90 expression in relation to psoriasis duration, recurrence, exacerbating factors, therapy, and comorbidities like metabolic and cardiovascular diseases.
Main Methods:
- Quantitative real-time PCR (qRT-PCR) was used to measure HSP90 mRNA levels.
- Skin biopsies from 40 psoriasis patients and 20 healthy controls were analyzed.
Main Results:
- Psoriatic patients exhibited significantly higher HSP90 mRNA expression compared to healthy controls.
- HSP90 expression positively correlated with the frequency of psoriasis exacerbations.
- Acute infections most significantly increased HSP90 expression among exacerbating factors.
Conclusions:
- HSP90 plays a significant role in psoriasis pathogenesis.
- Increased HSP90 expression is linked to psoriasis exacerbations, acute infections, emotional stress, and comorbidities like hyperlipidemia or diabetes in younger adults.
- HSP90 expression is independent of psoriasis type, cardiovascular comorbidities, smoking, and alcohol consumption.
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