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Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated

Sanjay J Chandnani1, Shubham Jain1, Pankaj Nawghare1

  • 1Department of Gastroenterology, Topiwala National Medical College & Bai Yamunabai Laxmanrao Nair Charitable Hospital, Mumbai, Maharashtra, India.

The Indian Journal of Medical Research
|February 8, 2023
PubMed

Insights

Liver function test abnormalities are common in COVID-19 patients and indicate a higher risk of severe disease and mortality. Deranged LFTs worsen outcomes and predict in-hospital death.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) can affect multiple organ systems, including the liver.
  • Data on liver involvement and liver function test (LFT) abnormalities in COVID-19 patients from India are limited.

Purpose of the Study:

  • To estimate the prevalence and characteristics of LFT abnormalities in COVID-19 patients.
  • To investigate the association between LFT derangements and disease severity, clinical outcomes, and mortality.

Main Methods:

  • Retrospective study of 1474 COVID-19 patients confirmed by RT-PCR at a tertiary care center in Mumbai, India.
  • Analysis of clinical characteristics, biochemical parameters (including LFTs), and patient outcomes.
  • Multivariate analysis to identify predictors of mortality.

Main Results:

  • 46% of patients exhibited deranged LFTs, predominantly hepatocellular injury (93%).
  • Deranged LFTs were significantly associated with increased risk of severe disease (P<0.001) and mortality (P<0.001).
  • Factors associated with deranged LFTs included advanced age, male gender, diabetes, low oxygen saturation, and high neutrophil-lymphocyte ratio.

Conclusions:

  • LFT abnormalities are frequent in COVID-19 patients and correlate with disease severity.
  • Deranged LFTs are indicative of poorer clinical outcomes and predict in-hospital mortality.
Abstract

Keywords:
COVID-19hepatitisliver function testsmortalityrespiratory distress syndrome –SARS-CoV-2

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