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Related Experiment Video

Updated: Aug 11, 2025

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Splenectomy does not affect mouse behaviors.

Jiao-Qiong Guan1, Pei-Sen Zhang2, Wen-Chao Zhang3

  • 1Department of Rehabilitation Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong Province; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neural Regeneration Research
|February 8, 2023
PubMed
Summary

This study found that removing the spleen (splenectomy) in mice did not affect their general behaviors, learning, memory, or susceptibility to stress-induced depression. Spleen removal does not alter baseline behavior in mice.

Keywords:
anxietychronic unpredictable mild stresscircadian rhythmsdepressionimmunitylearninglocomotionmemoryspleensplenectomy

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Area of Science:

  • Immunology
  • Neuroscience
  • Behavioral Science

Background:

  • The spleen is a major immune organ, but its direct role in behavior is not well understood.
  • Existing research links behavior and immunity in disease, but the spleen's specific behavioral influence remains unclear.

Purpose of the Study:

  • To investigate the impact of spleen removal (splenectomy) on various behavioral aspects in mice.
  • To determine if splenectomy affects general locomotion, circadian rhythms, learning, memory, anxiety, depression, or stress susceptibility.

Main Methods:

  • A splenectomy procedure was performed on C57BL/6J mice.
  • Mice underwent a battery of behavioral tests: open field, circadian rhythm, elevated plus maze, sucrose preference, and Barnes maze.
  • Depression models were induced using chronic unpredictable mild stress to assess stress susceptibility.

Main Results:

  • Splenectomy did not significantly alter general locomotion, circadian rhythms, learning and memory, or anxiety/depression-related behaviors.
  • Mice that underwent splenectomy showed no behavioral differences compared to control groups, even when subjected to stress-induced depression models.

Conclusions:

  • Spleen removal does not appear to induce changes in baseline behavioral performance in mice.
  • The spleen may not play a critical role in modulating the behaviors assessed in this study under normal or stressed conditions.