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Development of SEDDS formulation containing caffeine for dermal delivery
Igor de Andrade Assunção de Almeida1, Thiago da Silva Honório2, Flavia Almada do Carmo2
1Laboratory of Instrumental Analysis, Duque de Caxias Campus, Federal Institute of Rio de Janeiro, Rio de Janeiro, Brazil.
International Journal of Cosmetic Science
|February 8, 2023
Summary
This study developed a stable self-emulsifying drug delivery system (SEDDS) with caffeine to treat cellulite. The formulation enhances skin penetration, potentially increasing blood flow and reducing cellulite.
Area of Science:
- Pharmaceutical Sciences
- Dermatology
- Cosmetic Science
Background:
- Cellulite is a common cosmetic concern.
- Caffeine is a potential agent for cellulite treatment.
- Effective drug delivery systems are needed to enhance caffeine's topical efficacy.
Purpose of the Study:
- To develop a stable self-emulsifying drug delivery system (SEDDS) for caffeine.
- To evaluate the potential of caffeine SEDDS for cellulite treatment.
Main Methods:
- SEDDS formulation using the solution method with 0.5% caffeine.
- Characterization of SEDDS: droplet size, zeta potential, emulsification time, and stability.
- In vitro skin permeation studies using Franz-type diffusion cells.
- Cytotoxicity evaluation on human keratinocytes (HaCaT cells).
Main Results:
- Developed thermodynamically stable caffeine SEDDS with small droplet size (~30 nm) and negative zeta potential (< -22 mV).
- Formulation demonstrated long-term stability.
- Skin permeation studies indicated caffeine accumulation in skin layers, suggesting enhanced local circulation.
- Cytotoxicity results were inconclusive due to surfactant interference.
Conclusions:
- A stable caffeine SEDDS was successfully developed.
- The formulation shows potential for cellulite reduction by increasing local blood flow.
- Further investigation is needed to confirm efficacy and safety due to inconclusive cytotoxicity data.
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