Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Monogastric Digestion?01:50

What is Monogastric Digestion?

71.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.

Nature medicine·2026
Same author

Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.

Gut microbes·2026
Same author

Drivers of Research Participation Among Racially and Ethnically Underrepresented Women: Insights from Semi-Structured Interviews.

Journal of racial and ethnic health disparities·2026
Same author

Dihydropyridine Calcium Channel Blocker-induced Prescribing Cascades: Signal Detection using High-throughput Sequence Symmetry Analysis.

medRxiv : the preprint server for health sciences·2026
Same author

Artificial intelligence-enabled plaque characterization from coronary computed tomography establishes basis of angina in women with nonobstructive atherosclerosis.

Communications medicine·2026
Same author

Brachial Pulse Pressure and Outcomes: A Report From the WISE Study.

Hypertension (Dallas, Tex. : 1979)·2026

Related Experiment Video

Updated: Aug 11, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.2K

Host-Microbiota Communication in Spontaneously Hypertensive Rats Generates Unique IgA-Coated Gut Microbes.

Jing Li1,2, Elaine M Richards2, Ramakumar Tummala3

  • 1Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden Chinese Academy of Sciences Wuhan Hubei China.

Journal of the American Heart Association
|February 8, 2023
PubMed
Summary

Hypertension is linked to gut bacteria changes. This study identified specific immunoglobulin A (IgA)-coated gut microbes altered in hypertensive rats, offering potential therapeutic targets for managing blood pressure.

Keywords:
Immunoglobin A‐coated bacteriahost‐microbiota communicationhypertension

More Related Videos

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
07:21

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

258
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

8.8K

Related Experiment Videos

Last Updated: Aug 11, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.2K
Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
07:21

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

258
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

8.8K

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Hypertension is linked to gut dysbiosis, altered intestinal immunity, and gut pathology.
  • The specific functional gut microbes interacting with intestinal mucosa in hypertension remain largely unknown.

Purpose of the Study:

  • To identify specific immunoglobulin A (IgA)-coated bacteria interacting with the intestinal mucosa in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats.
  • To elucidate the role of these microbes in host-microbiota communication relevant to hypertension.

Main Methods:

  • Utilized magnetic-activated cell sorting and fluorescence-activated cell sorting to isolate IgA-coated (IgA+) and IgA-noncoated (IgA-) bacteria.
  • Performed 16S rRNA gene sequencing (IgA-SEQ) to analyze the microbial composition of these fractions in SHR and Wistar Kyoto rats.

Main Results:

  • Observed a significant decrease in IgA+ bacteria in SHR compared to Wistar Kyoto rats.
  • Identified distinct compositions of IgA+ and IgA- bacteria between rat groups, with SHR showing increased IgA-bound Proteobacteria, Bacteroidetes, and Actinobacteria, but less Firmicutes.
  • Found enriched IgA-coated Romboutsia, Turicibacter, Ileibacterium, and Dubosiella in SHR, negatively correlated with immune and epithelial pathways.

Conclusions:

  • Demonstrated novel IgA-coated bacteria involved in host-microbiota communication in hypertension.
  • These findings suggest potential therapeutic strategies targeting specific gut microbes for hypertension management.