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Related Experiment Video

Updated: Aug 11, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Using organ perfusion to optimize donor livers.

Grace S Lee-Riddle¹, Guergana G Panayotova, James V Guarrera

¹Division of Transplant and Hepatobiliary Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Current Opinion in Organ Transplantation

|February 8, 2023

Summary

Ex-vivo machine perfusion, including hypothermic (HMP) and normothermic (NMP) methods, improves outcomes for extended criteria donor (ECD) livers. These techniques offer future potential for optimizing donor organs and increasing liver transplants.

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Last Updated: Aug 11, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers

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Published on: May 26, 2015

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

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Published on: June 14, 2024

Area of Science:

Hepatology and Transplant Surgery
Organ Preservation Technologies

Background:

Donor organ shortage necessitates utilizing extended criteria donor (ECD) livers for liver transplantation.
Ex-vivo machine perfusion offers a method for organ assessment and treatment during preservation.
This approach may enable the safe use of ECD livers, which are at higher risk for adverse outcomes.

Conclusions:

Machine perfusion techniques (HMP and NMP) are effective in improving outcomes for ECD livers.
Future applications of machine perfusion hold promise for optimizing donor organs.
These advancements can potentially increase the number of liver transplants performed for patients on the waitlist.