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Related Experiment Video

Updated: Aug 11, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

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Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation.

Michael S Leapman1,2,3, Rong Wang2,3, Stacy Loeb4,5

  • 1Department of Urology, Yale School of Medicine, New Haven, Connecticut.

The Journal of Urology
|February 8, 2023
PubMed

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Summary
This summary is machine-generated.

Monitoring for localized prostate cancer shows increasing PSA testing and biopsy rates over time, but overall use of recommended tests remains low for Medicare beneficiaries on observation.

Area of Science:

  • Urology
  • Oncology
  • Health Services Research

Background:

  • Active surveillance for localized prostate cancer involves regular monitoring.
  • Compliance with recommended monitoring tests for prostate cancer is not well-documented over time.

Purpose of the Study:

  • To investigate trends in monitoring test utilization for prostate cancer.
  • To examine rates of PSA testing, prostate biopsy, and prostate MRI over time.
  • To identify factors associated with monitoring test frequency during observation.

Main Methods:

  • Retrospective cohort study of Medicare beneficiaries diagnosed with low- or intermediate-risk prostate cancer (2004-2016).
  • Analysis of PSA testing, prostate biopsy, and prostate MRI rates.
  • Multivariable mixed-effects Poisson regression used to assess temporal trends and associated factors.
Keywords:
biopsyprostate-specific antigenprostatic neoplasmswatchful waiting

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Last Updated: Aug 11, 2025

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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

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Main Results:

  • Over 10,000 patients were included, with a median follow-up of 4.3 years.
  • Rates of PSA testing and prostate biopsy increased significantly over time.
  • Despite increases, 5-year monitoring showed 98% received PSA tests, 48% a biopsy, and 31% an MRI.

Conclusions:

  • Monitoring test utilization, including repeat prostate biopsies, remains low for Medicare beneficiaries on observation for prostate cancer.
  • Temporal trends show an increase in PSA testing and biopsy rates.
  • Clinical and sociodemographic factors influence monitoring test frequency.