Related Experiment Video
Updated: Aug 11, 2025
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Video-Based Deep Learning for Automated Assessment of Left Ventricular Ejection Fraction in Pediatric Patients
Charitha D Reddy1, Leo Lopez1, David Ouyang2
1Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Background:
Significant interobserver and interstudy variability occurs for left ventricular (LV) functional indices despite standardization of measurement techniques. Artificial intelligence models trained on adult echocardiograms are not likely to be applicable to a pediatric population. We present EchoNet-Peds, a video-based deep learning algorithm, which matches human expert performance of LV segmentation and ejection fraction (EF).
Methods:
A large pediatric data set of 4,467 echocardiograms was used to develop EchoNet-Peds. EchoNet-Peds was trained on 80% of the data for segmentation of the left ventricle and estimation of LVEF. The remaining 20% was used to fine-tune and validate the algorithm.
Results:
In both apical 4-chamber and parasternal short-axis views, EchoNet-Peds segments the left ventricle with a Dice similarity coefficient of 0.89. EchoNet-Peds estimates EF with a mean absolute error of 3.66% and can routinely identify pediatric patients with systolic dysfunction (area under the curve of 0.95). EchoNet-Peds was trained on pediatric echocardiograms and performed significantly better to estimate EF (P < .001) than an adult model applied to the same data.
Conclusions:
Accurate, rapid automation of EF assessment and recognition of systolic dysfunction in a pediatric population are feasible using EchoNet-Peds with the potential for far-reaching clinical impact. In addition, the first large pediatric data set of annotated echocardiograms is now publicly available for efforts to develop pediatric-specific artificial intelligence algorithms.
