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Contribution of Interleukin-6 system genes polymorphisms to the development of coronary atherosclerosis

Yulia A Shuvalova1, Victoria Kaminnaya2, Alexander I Kaminnyi1

  • 1FSBI Academician E I Chazov National Medical Research Centre of Cardiology of the Ministry of Health of the Russian Federation, Department of Atherosclerosis Problems, 3rd Cherepkovskaya str, 15a, Moscow 121552, Russia.

Gene
|February 8, 2023
PubMed

Insights

Coronary artery disease (CAD) is a major cause of death. This review explores the genetic factors, focusing on the interleukin-6 system, contributing to atherosclerosis development and prevention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Immunology

Background:

  • Coronary artery disease (CAD) is a leading cause of cardiovascular morbidity and mortality.
  • Atherosclerosis risk involves complex genetic, environmental, and lifestyle interactions.
  • Aging populations are projected to increase CAD prevalence, highlighting prevention needs.

Purpose of the Study:

  • To review current knowledge on the genetics of atherosclerosis.
  • To specifically examine the role of the interleukin-6 (IL-6) system in coronary atherosclerosis development.

Main Methods:

  • Literature review and synthesis of existing research.
  • Focus on genetic studies related to atherosclerosis.
  • Analysis of the interleukin-6 system's genetic components and pathways.

Main Results:

  • Significant advancements in understanding atherosclerosis genetics have occurred.
  • The interleukin-6 system is implicated in the pathogenesis of coronary atherosclerosis.
  • Genetic variations within the IL-6 system may influence disease susceptibility.

Conclusions:

  • Understanding the genetic basis of CAD, particularly the IL-6 system, is crucial for effective prevention.
  • Further research into IL-6 genetics can inform targeted therapeutic strategies.
  • Genetics plays a significant role in atherosclerosis, necessitating personalized prevention approaches.

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