Related Experiment Video
Updated: Jul 11, 2026
10:55
Rescue of Recombinant Newcastle Disease Virus from cDNA
Published on: October 12, 2013
Interaction between chicken lymphocytes and Newcastle disease virus
1Department of Epidemiology and Preventive Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Avian Diseases
|July 1, 1987
Summary
Newcastle disease virus (NDV) infects chicken lymphocytes and Marek's disease tumor cells. The virus causes cell fusion and lysis while supporting its own growth and multiplication.
Area of Science:
- Virology
- Immunology
- Cell Biology
Background:
- Newcastle disease virus (NDV) is a significant pathogen in poultry.
- Understanding NDV's interaction with host cells is crucial for disease control.
Purpose of the Study:
- To investigate the interaction between different Newcastle disease virus strains and avian host cells.
- To determine the effects of NDV infection on chicken lymphocytes and Marek's disease tumor cell lines.
Main Methods:
- Exposure of chicken lymphocytes and Marek's disease tumor cell lines (JMV-1, MSB-1) to various NDV strains.
- Microscopic observation and cell viability assays to assess virus-cell interactions.
Main Results:
- NDV induced significant cell fusion and lysis in both lymphocyte and tumor cell lines.
- The tested avian cell lines effectively supported the replication and multiplication of NDV.
Conclusions:
- NDV exhibits direct cytopathic effects on susceptible avian cells, including fusion and lysis.
- Avian lymphocytes and Marek's disease tumor cells are permissive to NDV infection and support viral propagation.
More Related Videos
Related Concept Videos
00:57Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
01:51Vaccinations
Overview
01:29Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
01:20Chickenpox
Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...