Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

134
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
134
Diffusion01:21

Diffusion

4.3K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of aerobic threshold assessment using a sweat lactate sensor during arm crank exercise by healthy adults.

Physiological reports·2026
Same author

Mapping of motor and non-motor symptoms to 12-region dopamine transporter single-photon emission computed tomography in Parkinson's disease.

Journal of neurology·2026
Same author

Anatomic Variations of the Zygomatic Arch: Rethinking the Indications for the Orbitozygomatic Approach.

Neurologia medico-chirurgica·2026
Same author

Performance of large language models on the Japanese cardiovascular surgery board examination: a comparative analysis of eight contemporary AI models with educational implications.

General thoracic and cardiovascular surgery·2026
Same author

Whole-brain connectome analysis for elucidating specific structural neural networks in idiopathic normal-pressure hydrocephalus.

Magma (New York, N.Y.)·2026
Same author

Effects of perfusion fixation on whole-brain structural connectivity in marmoset: a diffusion MRI analysis.

Radiological physics and technology·2026

Related Experiment Video

Updated: Aug 11, 2025

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K

Influence of Diffusion Time and Temperature on Restricted Diffusion Signal: A Phantom Study.

Hinako Oshiro1,2, Junichi Hata1,2,3,4, Daisuke Nakashima3

  • 1Graduate School of Human Health Sciences, Tokyo Metropolitan University.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|February 8, 2023
PubMed
Summary

This study characterized restricted diffusion using capillary phantoms, revealing how structure scale, temperature, and diffusion time influence water molecule displacement. Findings suggest temperature effects on diffusion coefficients adhere to physical laws.

Keywords:
capillarydiffusion magnetic resonance imagingrestricted diffusiontemperature-dependent magnetic resonance imagingtime-dependent magnetic resonance imaging

More Related Videos

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

11.5K
Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.0K

Related Experiment Videos

Last Updated: Aug 11, 2025

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K
From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

11.5K
Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.0K

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Diffusion MRI Physics
  • Water Diffusion Characterization

Background:

  • Diffusion MRI quantifies water molecule displacement in voxels.
  • Limited data exists on physical diffusion characterization in uniform structures like phantoms.
  • Understanding restricted diffusion is crucial for various applications.

Purpose of the Study:

  • To investigate the relationship between structure scale, temperature, and diffusion time in simple restricted diffusion.
  • To utilize a capillary phantom for quantitative diffusion measurements.
  • To characterize the transitional behavior of diffusion coefficients under varying conditions.

Main Methods:

  • Diffusion-weighted pulsed-gradient stimulated-echo acquisition mode (STEAM) MRI was employed.
  • Experiments were conducted using a 9.4 Tesla MRI system.
  • Capillary plates with varying pore sizes (6-100 μm) were measured at temperatures (10-40°C) and diffusion times (12-800 ms) to determine radial diffusivity (RD).

Main Results:

  • Radial diffusivity (RD) showed decay and stabilization based on structural scale.
  • Temperature-induced diffusion coefficient fluctuations were prominent at larger scales and shorter diffusion times.
  • Experimental data indicated that temperature dependencies of diffusion coefficients align with physical laws.

Conclusions:

  • Capillary plates accurately modeled restricted diffusion within their structures.
  • The study successfully revealed the interplay between diffusion coefficient, diffusion time, structure scale, and temperature.
  • These findings provide a foundational understanding of restricted diffusion physics.