Phycotoxins and marine annelids - A global review

Several species of microalgae can produce potent phycotoxins that negatively affect aquatic organisms and their consumers following different exposure routes, as well as toxicokinetic (TK) and toxicodynamic (TD) processes. Benthic organisms are especially vulnerable as they are exposed to both benthic and planktonic species causative of harmful algal blooms (HABs). While benthic algae can come into direct contact with annelids during substrate remobilization, planktonic cells can settle to the bottom mostly during senescence and/or encystment stages, and in shallow and calm waters. We performed a systematic, qualitative review of the literature on the phycotoxin TK and TD processes in marine annelids, summarizing the most relevant findings and general trends. Besides, by using innovative analytical/statistical approaches, we were able to detect patterns and gaps in the current literature, thus pointing to future research directions. We retrieved and analyzed studies involving diarrhetic shellfish toxins (DSTs), paralytic shellfish toxins (PSTs), brevetoxins (PbTXs), domoic acid (DA), as well as palytoxin and its congeners, the ovatoxins (treated together as PLTXs). It is worth mentioning that studies evaluating other phycotoxins (e.g., ciguatoxins, yessotoxins) were not found in the literature. The absence of data on PbTXs, PSTs and DA is the largest gap hampering TK assessment in annelids, although some relevant information on TD is already available. Whereas lethal effects from DSTs have not been reported, more potent toxins like PbTXs, PSTs, DA and those grouped as PLTX-like compounds can cause mortality and/or marked decrease in annelid abundance. In addition, phycotoxins have been linked to sublethal effects on annelid cells. Although very sparse, field and laboratory studies offer strong evidence that annelids may be reliable indicators of toxin exposure and their negative effects during both early and later stages of HABs in marine environments. Besides quickly responding to these compounds at both organismic and suborganismic levels, annelids are easily found in areas affected by HABs. The use of annelids in future investigations evaluating the action mechanisms of toxic microalgae on marine invertebrates should be thus encouraged. In this case, the choice for widely dispersed and numerically dominant species of annelids would strengthen the validation and extrapolation of results from risk assessments in areas affected by HABs worldwide.