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Intervention with Therapeutic Agents, Understanding the Path to Remission in Type 2 Diabetes: Part 1

Shuai Hao1, Guillermo E Umpierrez2, Tanicia Daley1

  • 1Division of Pediatric Endocrinology, Children's Healthcare of Atlanta, Emory University School of Medicine, 1400 Tullie Road Northeast, Atlanta, GA 30329, USA.

Endocrinology and Metabolism Clinics of North America
|February 8, 2023
PubMed

Insights

Type 2 diabetes in youth rapidly impairs pancreatic beta-cell function. Intensive therapies may temporarily delay decline, but remission is challenging with current medications.

Area of Science:

  • Endocrinology
  • Metabolic disorders
  • Diabetes research

Background:

  • Type 2 diabetes involves progressive pancreatic beta-cell dysfunction.
  • Adults with type 2 diabetes may delay beta-cell decline with intensive therapy, but benefits cease upon treatment withdrawal.
  • Youth with type 2 diabetes exhibit faster beta-cell function loss than adults, even with medication.

Purpose of the Study:

  • To review studies on achieving diabetes remission in youth.
  • To evaluate the efficacy of insulin and oral antidiabetic medications in preserving beta-cell function.

Main Methods:

  • Review of existing studies on type 2 diabetes treatment in youth.
  • Analysis of therapeutic strategies involving insulin and oral antidiabetic agents.

Main Results:

  • Youth with type 2 diabetes show accelerated beta-cell decline compared to adults.
  • Current antihyperglycemic medications, including insulin, do not prevent beta-cell loss in this population.
  • Therapeutic improvements are often temporary and lost upon cessation.

Conclusions:

  • Achieving sustained diabetes remission in youth with type 2 diabetes remains a significant challenge.
  • Further research is needed to develop effective long-term strategies for preserving beta-cell function in pediatric populations.
Keywords:
Diabetes remissionDrug-free remissionType 2 diabetes mellitusβ-cell preservation

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