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Updated: Aug 11, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats.

Leslie S Gaynor¹, Meena Ravi^2,3, Sabrina Zequeira^2,3

¹Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158.

|February 8, 2023

Summary

This summary is machine-generated.

Cognitive training in aged rats enhanced brain network connectivity, suggesting a compensatory mechanism for age-related cognitive decline. This improvement was specific to cognitive training, not general reward-seeking behavior.

Keywords:

associative memory cognitive aging cognitive training functional connectivity graph theory medial temporal lobe

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Last Updated: Aug 11, 2025

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Neuroscience
Aging Research
Cognitive Science

Background:

Age-related cognitive decline involves disruptions in brain networks.
Interventions targeting large-scale brain networks may improve cognitive function in older adults.
Understanding brain connectivity changes is crucial for developing effective cognitive strategies.

Purpose of the Study:

To investigate the impact of cognitive training on resting-state functional connectivity in young and aged rats.
To examine age-related changes in specific brain regions associated with associative memory.
To identify potential compensatory mechanisms engaged by cognitive training.

Main Methods:

Utilized a computerized paired-associates learning (PAL) task for cognitive training.
Employed resting-state functional connectivity MRI to assess brain network changes.
Analyzed seed-based connectivity in medial temporal lobe, retrosplenial cortex, and frontal cortical areas.

Main Results:

Cognitive training led to increased global functional connectivity in aged rats, unlike young rats or a control group.
Specific increases in connectivity were observed between perirhinal and prelimbic cortices in aged, trained rats.
Reduced reciprocal connectivity within the retrosplenial cortex was noted in aged, trained rats.

Conclusions:

Cognitive training can modulate brain network connectivity in aged individuals.
Increased global and regional connectivity may represent compensatory mechanisms against cognitive aging.
These findings support cognitive training as a potential strategy to mitigate age-related cognitive decline.