Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

28.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.6K
Gastrulation01:56

Gastrulation

57.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.9K
Whole Body Regeneration01:33

Whole Body Regeneration

3.4K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.4K
Neurulation01:30

Neurulation

42.2K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.2K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

5.4K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.4K
Determination01:51

Determination

18.7K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DySTrack - a modular smart microscopy tool for live tracking of dynamic samples on modern commercial microscopes.

Journal of cell science·2026
Same author

Force coordination distinguishes epithelial and mesenchymal modes of collective chemotaxis.

The Journal of cell biology·2026
Same author

Celebrating a century of the Spemann-mangold experiment: Self-organisation in biology.

Cells & development·2025
Same author

Neural Crest Migration Orchestrated by Molecular and Mechanical Signals.

Annual review of cell and developmental biology·2025
Same author

Forcing cell fate.

Nature cell biology·2025
Same author

Patterning in motion: Cell interfaces guide mesenchymal collective migration and morphogenesis.

The Journal of cell biology·2025

Related Experiment Video

Updated: Aug 11, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.2K

Generative models of morphogenesis in developmental biology.

Namid R Stillman1, Roberto Mayor2

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

Seminars in Cell & Developmental Biology
|February 8, 2023
PubMed
Summary

This review explores mathematical models of cell migration and differentiation in developmental biology. It highlights how machine learning can improve these models, making them more data-driven and robust for studying biological processes.

Keywords:
Cell migrationComputational biologyDevelopmental biologyGenerative modelsSimulation-based inference

More Related Videos

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.3K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.5K

Related Experiment Videos

Last Updated: Aug 11, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.2K
Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.3K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.5K

Area of Science:

  • Developmental Biology
  • Mathematical Modeling
  • Machine Learning

Background:

  • Cell differentiation and migration are crucial for development, wound healing, and disease.
  • Mathematical models are vital for understanding these cellular processes.
  • Existing models face challenges with data integration and parameter constraints.

Purpose of the Study:

  • To review mathematical models of cell migration and differentiation.
  • To explore the integration of machine learning with these models.
  • To enhance the development and application of predictive biological models.

Main Methods:

  • Review of existing mathematical models (e.g., soft particle, reaction-diffusion, multi-scale simulations).
  • Discussion of recent machine learning techniques applicable to biological modeling.
  • Analysis of how machine learning can address limitations in current models.

Main Results:

  • Mathematical models offer insights into cell coordination.
  • Machine learning provides novel approaches for model derivation and deployment.
  • Combining machine learning with mathematical models can lead to more accurate and constrained predictions.

Conclusions:

  • Machine learning integration offers a promising avenue for advancing cell migration and differentiation models.
  • This synergy can improve our understanding of fundamental biological processes.
  • Future research should focus on developing and validating these hybrid modeling approaches.