Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

20
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
20
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

481
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
481
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

412
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
412
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

31
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
31
Alterations in Respiration II01:30

Alterations in Respiration II

945
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
945

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventricular Arrhythmias and Implantable Cardioverter-Defibrillator Therapy in Women: A Propensity Score-Matched Analysis.

JACC. Clinical electrophysiology·2022
Same author

Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats.

Scientific reports·2019
Same author

Cardiovascular variability is similarly altered in coronary patients with normal left ventricular function and in heart failure patients.

Journal of hypertension·2014
Same author

Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof-of-concept study.

European journal of heart failure·2014
Same author

Do apolipoproteins improve coronary risk prediction in subjects with metabolic syndrome? Insights from the North Italian Brianza cohort study.

Atherosclerosis·2014
Same author

Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies.

Diabetologia·2014

Related Experiment Video

Updated: Aug 11, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

5.2K

Respiratory patterns and baroreflex function in heart failure.

Alberto Radaelli1, Giuseppe Mancia2, Giulia Balestri3

  • 1Division of Cardiac Rehabilitation, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi, 33, 20900, Monza, MB, Italy. albertorada13@gmail.com.

Scientific Reports
|February 9, 2023
PubMed
Summary
This summary is machine-generated.

Heart failure patients exhibit altered breathing patterns affecting baroreflex sensitivity (BRS). Slowing respiration improves BRS in heart failure, suggesting breathing exercises may aid cardiovascular control.

More Related Videos

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.5K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

741

Related Experiment Videos

Last Updated: Aug 11, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

5.2K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.5K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

741

Area of Science:

  • Cardiology
  • Respiratory Physiology
  • Autonomic Nervous System Function

Background:

  • Baroreflex sensitivity (BRS) is crucial for cardiovascular regulation.
  • The impact of respiratory patterns on BRS in heart failure (HF) is not well understood.
  • HF patients often exhibit autonomic dysfunction, potentially influenced by breathing.

Purpose of the Study:

  • To investigate the effects of different respiratory patterns on baroreflex sensitivity in patients with heart failure.
  • To compare BRS between HF patients and healthy controls under various breathing conditions.
  • To explore the relationship between respiratory modulation and baroreflex control in HF.

Main Methods:

  • Recruited 30 HF patients and 10 healthy controls (CNT).
  • Monitored R-R interval (RRI), systolic arterial blood pressure (SBP), and respiratory signals (RSP).
  • Recorded data during free-breathing, fast-paced (≥12 bpm), and slow-paced (6 bpm) breathing sessions.

Main Results:

  • HF patients showed greater very-low-frequency (VLF) respiratory modulation during free-breathing compared to CNT.
  • During fast-paced breathing, HF patients had significantly lower BRS than CNT and lower than their own free-breathing BRS.
  • Slow-paced breathing increased BRS in HF patients compared to fast-paced breathing.

Conclusions:

  • HF patients exhibit distinct VLF respiratory volume modulation during free-breathing.
  • Respiratory modulation in VLF and low-frequency ranges contributes to preserving baroreflex-mediated heart rate control in HF.
  • Altering respiratory patterns, specifically slow-paced breathing, can modulate BRS in HF patients.