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Albumin-based nanoparticles: small, uniform and reproducible
Gudrun C Thalhammer-Thurner1,2,3, Paul Debbage1
1Division of Histology and Embryology, Department of Anatomy, Medical University Innsbruck Müllerstrasse 59 6020 Innsbruck Austria Gudrun.Thurner@i-med.ac.at.
Nanoscale Advances
|February 9, 2023
Summary
Researchers developed Absicles, novel albumin nanoparticles for precise lesion targeting. These stable, reproducible, and scalable nanoparticles show promise for future drug delivery applications in nanomedicine.
Area of Science:
- Nanomedicine
- Biomaterials Science
- Drug Delivery Systems
Background:
- Reproducible synthesis of sub-50 nm monodisperse protein nanoparticles for in vivo applications remains a challenge.
- Scalable industrial production of such nanoparticles is crucial for clinical translation.
- Existing nanomedicine platforms face limitations in stability and cost-effectiveness.
Purpose of the Study:
- To develop a novel, reproducible, and scalable method for synthesizing monodisperse protein nanoparticles.
- To characterize the physical properties, stability, and targeting capabilities of these nanoparticles.
- To evaluate the potential of these nanoparticles as a platform for drug delivery.
Main Methods:
- Albumin-based nanoparticles, termed Absicles, were synthesized using a proprietary procedure.
- Absicle size was tuned within a range of 15 nm to 70 nm.
- Stability against decomposition and aggregation was assessed over several months.
- Specificity of Absicles with targeting groups for colon carcinoma tissue was evaluated ex vivo.
Main Results:
- Absicles were successfully synthesized with tunable diameters (15-70 nm) and high monodispersity.
- The nanoparticles demonstrated excellent long-term stability, exceeding many months.
- The synthesis process exhibited high reproducibility, simplicity, and cost-effectiveness for up-scaling.
- Targeted Absicles showed high specificity for colon carcinoma tissue ex vivo.
Conclusions:
- Absicles represent a promising, stable, and reproducible nanomedicine platform.
- Their tunable size, cost-effective synthesis, and targeting ability make them attractive for drug delivery.
- Further development of Absicles holds potential for precise in vivo lesion identification and treatment.
