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Immunoblastic lymphosarcoma: a light, immunofluorescence, and electron microscopic study.

R P Michel, B W Case, M Moinuddin

    Cancer
    |January 1, 1979
    PubMed
    Summary
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    Immunoblastic lymphosarcoma (ILS) is a B-cell lymphoma often seen in older adults. Diagnosis using immunofluorescence and electron microscopy aids in identifying this aggressive cancer with a poor prognosis.

    Area of Science:

    • Hematology
    • Oncology
    • Immunopathology

    Background:

    • Immunoblastic lymphosarcoma (ILS) is a recently classified malignant lymphoreticular neoplasm.
    • This neoplasm is included in the World Health Organization (WHO) classification of lymphomas.

    Observation:

    • Six ILS cases were analyzed using light microscopy, immunofluorescence (IF), and electron microscopy (EM).
    • Patients were predominantly female, over 50, with some exhibiting immunological abnormalities.
    • Light microscopy revealed monomorphic immunoblasts; IF detected intracytoplasmic IgG or IgA.

    Findings:

    • Electron microscopy showed large lymphoid cells with abundant organelles, consistent with active protein synthesis.
    • Four of six patients had B-cell origin confirmed by immunophenotyping.

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  • Mean survival was short (4.8 months), with disseminated disease causing death in most.

    • Implications:

    • ILS is a B-cell lymphoma often linked to immune dysfunction and carrying a grave prognosis.
    • Immunofluorescence and electron microscopy are crucial for accurate ILS diagnosis.
    • Further research into ILS pathogenesis and treatment is warranted.