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The predictive value of the systemic immune-inflammatory index for left atrial appendage thrombus in non-valvular

Fatih Koca1, Fatih Levent1, Baris Sensoy1

  • 1Bursa Education and Research Hospital, University of Health Sciences, Bursa, Turkey.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|February 9, 2023
PubMed

Insights

The systemic immune inflammatory index (SII) can predict left atrial appendage (LAA) thrombus in non-valvular atrial fibrillation patients. This accessible test aids in determining anticoagulant therapy decisions.

Area of Science:

  • Cardiology
  • Hematology
  • Inflammation Research

Background:

  • The systemic immune inflammatory index (SII) is recognized for its prognostic capabilities in cardiovascular diseases.
  • Non-valvular atrial fibrillation (NVAF) poses a significant risk for thromboembolic events, particularly left atrial appendage (LAA) thrombus formation.

Purpose of the Study:

  • To evaluate the predictive value of the SII for the presence of LAA thrombus in patients diagnosed with NVAF.
  • To determine if SII can serve as a biomarker for guiding anticoagulant treatment decisions in this patient cohort.

Main Methods:

  • A cohort of 525 patients with newly diagnosed NVAF, treatment-naïve for anticoagulation, were included.
  • Transesophageal echocardiography was performed on all participants to assess for LAA thrombus.
  • Multivariate regression analysis and ROC curve analysis were employed to identify predictors of LAA thrombus.

Main Results:

  • Left atrial appendage thrombus was identified in 16.4% of the study population.
  • The SII demonstrated significant diagnostic power for LAA thrombus (AUC: 0.760, P<0.001).
  • Independent predictors for LAA thrombus included diabetes, LAA emptying rate <20 cm/s, and an SII value >750 (all P<0.05).

Conclusions:

  • The SII is a practical and readily available marker that effectively predicts LAA thrombus in patients with NVAF.
  • The findings suggest that SII can be a valuable tool in clinical decision-making regarding anticoagulant therapy for NVAF patients.
Abstract

Keywords:
atrial fibrillationdiabetesleft atrial appendage thrombussystemic immune-inflammatory index

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