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Therapeutic effects of sofalcone on experimental gastritis
S Kishimoto1, K Okamoto, A Kambara
1First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Arzneimittel-Forschung
|August 1, 1987
Abstract:
A study was made on the therapeutic effects of sofalcone (SU-88), an antiulcer agent, on erosive and atrophic gastritis induced experimentally by 6-month administration of 5 mmol/l of sodium taurocholate (TCA) in rats. A standard meal including sofalcone of 0.25% and 1.0% shortened the total length of erosions, normalized the mucosal thickness, and reduced collagenous fibers in the gastric mucosa in one month. The doses administered were 116.3 mg and 486.1 mg/kg/week for one month. Sofalcone, thus, had a good therapeutic effect on experimental erosive and atrophic gastritis in rats.