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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

874
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
874
Allergic Drug Reactions01:27

Allergic Drug Reactions

916
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
916
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

211
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
211
Pharmacovigilance01:19

Pharmacovigilance

937
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
937
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

127
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
127
Analgesia and Pain Management01:25

Analgesia and Pain Management

708
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
708

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Related Experiment Video

Updated: Aug 11, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

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Recent Updates in Understanding NSAID Hypersensitivity.

Ellen Minaldi1, Katherine Cahill2

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Current Allergy and Asthma Reports
|February 9, 2023
PubMed
Summary
This summary is machine-generated.

Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity diagnosis and management rely on oral provocation tests. Understanding NSAID hypersensitivity phenotypes is crucial for safe treatment and managing cross-reactivity risks.

Keywords:
AspirinCOX-2 inhibitorsNSAID hypersensitivityOral provocation testUrticaria

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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Area of Science:

  • Clinical Immunology
  • Pharmacology
  • Allergy and Immunology

Background:

  • Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity is a significant clinical concern.
  • Distinct phenotypes of NSAID hypersensitivity exist, each with unique characteristics.
  • Recent literature highlights evolving diagnostic and management strategies.

Purpose of the Study:

  • To review current literature on nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity.
  • To emphasize recent findings and advancements in the field.
  • To provide an updated overview for clinicians and researchers.

Main Methods:

  • Comprehensive literature search of available studies on NSAID hypersensitivity.
  • Focus on recent publications and clinical findings.
  • Analysis of diagnostic approaches, cross-reactivity patterns, and treatment outcomes.

Main Results:

  • Oral provocation tests with aspirin are key for diagnosis and management in both adults and children.
  • Cross-reactivity risk with COX-2 inhibitors varies by NSAID hypersensitivity phenotype.
  • Aspirin-exacerbated respiratory disease patients tolerate COX-2 inhibitors; NSAID allergy is linked to substance use disorder risk.
  • Treating chronic spontaneous urticaria can enable NSAID tolerance in NSAID-exacerbated cutaneous disease.
  • Pathophysiology, cross-reactivity, and diagnostics differ across five distinct NSAID hypersensitivity phenotypes.

Conclusions:

  • Accurate diagnosis and understanding of NSAID hypersensitivity phenotypes are essential for patient care.
  • Further research is needed to elucidate the pathophysiology of NSAID hypersensitivity.
  • Personalized approaches to diagnosis and management are critical for patients with NSAID hypersensitivity.