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Updated: Aug 11, 2025

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy
Published on: March 6, 2017
How deeply should we analyze non-covalent interactions?
1Computer-Chemistry-Center, Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuernberg, Naegelsbachstrasse 25, 91052, Erlangen, Germany. Tim.Clark@fau.de.
Context:
Just how much effort and detail should we invest in analyzing interactions of the order of 5 kcal mol-1? This comment attempts to provide a conciliatory overview of what is often a contentious field and to pose some questions that I hope will eventually lead at least to some consensus.
Methods:
This is an opinion article without calculations or data.
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