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Updated: Aug 11, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases
Fernando Hernández-Bello1,2, Martha Franco3, Óscar Pérez-Méndez1
1Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México.
Abstract:
Sphingolipids (sphingomyelin, glycolipids, gangliosides) are located in cell membranes, plasma, and lipoproteins. In patients with cardiovascular, renal, and metabolic diseases, the profile of sphingolipids and their metabolites (ceramide, sphingosine, and sphingosine-1-phosphate) is modified, and these changes may explain the alterations in some cellular responses such as apoptosis. Furthermore, sphingosine and sphingosine-1-phosphate have been suggested to prevent COVID-19. This review also briefly mentions the techniques that allow us to study sphingolipids and their metabolites.
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