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Development of an imaging flow cytometer.

S H Ong¹, D Horne, C K Yeung

¹School of Electrical Engineering, University of Sydney, New South Wales, Australia.

Analytical and Quantitative Cytology and Histology

|October 1, 1987

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A new cell analyzer merges image and flow cytometry for advanced cell analysis. This instrument uses sophisticated image processing to classify and sort cells, aiding tumor heterogeneity studies.

Area of Science:

Biomedical Engineering
Cell Biology
Analytical Chemistry

Background:

Traditional cell analysis methods like flow cytometry and image cytometry have limitations.
There is a need for advanced instruments capable of detailed cellular analysis.

Purpose of the Study:

To describe the design and preliminary applications of a novel cell analyzer.
To introduce an instrument combining image and flow cytometry for enhanced cell classification and sorting.

Main Methods:

Cells stained with fluorescent dye are processed through a hydraulic system to a flow channel.
A laser beam illuminates cells, and a 2D charge-coupled device captures cell images.
Image processing and classification are performed using a specialized computer with parallel processors.

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Main Results:

The analyzer integrates morphologic, immunologic, and biochemical information for cell classification.
It is designed to classify and sort up to 500 cells per second.
Preliminary applications demonstrate its potential in various cell analysis tasks.

Conclusions:

The developed cell analyzer offers a unique combination of image and flow cytometry capabilities.
This instrument is particularly valuable for studying tumor heterogeneity.
The technology has the potential to advance cell analysis in research and diagnostics.