Related Experiment Video
Updated: Aug 11, 2025

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
Published on: August 21, 2015
Chemogenetic activation of lateral habenula accelerates the extinction of the appetitive conditioned responses
Dong-Hee Kim1, Bo-Ryoung Choi1, In-Beom Jin1
1Department of Biological Sciences, Konkuk University.
Abstract:
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Related Concept Videos
Conditioned Taste Aversion
A notable characteristic of conditioned taste aversion is that it often requires only a single...
Regulation of Food Intake
Long-term Potentiation
Hebbian LTP
LTP can occur when...

