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Updated: Aug 11, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Direct Heteroarylation Guidelines for Well-Defined Thiophene-Based Conjugated Molecules
Mona Hamidzad Sangachin1, Samuel Brassard1, Mario Leclerc1
1Université Laval, Département de Chimie, Québec City G1V 0A6, Canada.
Abstract:
Direct (hetero)arylation polymerization (DHAP) shows great promise for simple, low cost, and benign preparation of conjugated polymers. However, coupling selectivity has always posed a problem. Herein, direct (hetero)arylation was studied on small molecule models to develop suitable conditions for C-C couplings between 2-methylthiophene acting as an electron-donating moiety and 2-thiophenecarbonitrile acting as an electron-withdrawing moiety, when one of the partners is brominated. We observed that the best conditions are obtained when the electron-withdrawing moiety is halogenated.
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