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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Progress and promise of cell sheet assisted cardiac tissue engineering in regenerative medicine
Hadis Abdolahzadeh1, Niloofar Khoshdel Rad1, Anastasia Shpichka2,3,4
1Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Insights
Cardiac tissue engineering (CTE) offers a novel approach to regenerate heart tissue and improve function after cardiovascular diseases (CVDs). This review explores cell types, methods, and applications of CTE for cardiac repair.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Cardiovascular diseases (CVDs) are a leading cause of premature death globally.
- Effective strategies for CVD prevention, management, and monitoring are crucial.
- Recreating complex cardiac structures in vitro remains a significant challenge in tissue engineering.
Purpose of the Study:
- To review current and prospective strategies in cardiac regenerative medicine.
- To explore the applications of cell-sheet-assisted cardiac tissue engineering (CTE) for cardiac diseases.
- To evaluate the potential of CTE in improving cardiac regeneration and function.
Main Methods:
- Overview of various cell types used in cardiac regenerative medicine.
- Discussion of different approaches in cardiac tissue engineering.
- Analysis of cell-sheet-assisted CTE applications and outcomes.
Main Results:
- Cell-sheet-assisted CTE shows promise as an alternative for cardiac regenerative medicine.
- This technology has demonstrated potential in preclinical and clinical models for cardiac repair.
- Various cell types and engineering strategies are being investigated for enhanced cardiac regeneration.
Conclusions:
- Cardiac tissue engineering presents a novel therapeutic avenue for cardiovascular diseases.
- Cell-sheet technology is a key advancement in CTE for improving cardiac function.
- Further research in CTE holds significant potential for clinical translation in cardiac regenerative medicine.
Abstract:
Cardiovascular diseases (CVDs) are the most common leading causes of premature deaths in all countries. To control the harmful side effects of CVDs on public health, it is necessary to understand the current and prospective strategies in prevention, management, and monitoring CVDs.In vitro,recapitulating of cardiac complex structure with its various cell types is a challenging topic in tissue engineering. Cardiac tissue engineering (CTE) is a multi-disciplinary strategy that has been considered as a novel alternative approach for cardiac regenerative medicine and replacement therapies. In this review, we overview various cell types and approaches in cardiac regenerative medicine. Then, the applications of cell-sheet-assisted CTE in cardiac diseases were discussed. Finally, we described how this technology can improve cardiac regeneration and function in preclinical and clinical models.
