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Updated: Aug 11, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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The potential role of m6A modifications on immune cells and immunotherapy

Linchuan Gan1, Yuxiang Zhao1, Yajuan Fu1

  • 1Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University Qishan Campus, College Town, Fuzhou, Fujian Province 350117, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 9, 2023
PubMed

Insights

N6-methyladenosine (m6A) RNA modifications are crucial for immune cell balance and cancer development. Understanding m6A

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Immunology

Background:

  • N6-methyladenosine (m6A) is the most common RNA modification in mammals.
  • m6A dysregulation affects RNA processing, immune homeostasis, and tumor progression.

Purpose of the Study:

  • To summarize m6A's role in immune cell anti-tumor and self-homeostasis.
  • To explore how tumor-intrinsic m6A affects the tumor microenvironment.
  • To discuss m6A inhibitors for cancer therapy.

Main Methods:

  • Literature review and synthesis of current research on m6A modifications.
  • Analysis of m6A's impact on immune cell function and tumor development.
  • Review of targeted m6A inhibitor strategies.

Main Results:

  • m6A modifications are critical regulators of immune cell homeostasis and anti-tumor immunity.
  • Tumor cell m6A dysregulation influences immune cell activity within the tumor microenvironment.
  • Specific m6A inhibitors show promise for cancer treatment.

Conclusions:

  • m6A plays a significant role in both immune regulation and cancer progression.
  • Targeting m6A pathways offers a potential therapeutic strategy for cancer.
  • Further research into m6A modulators is warranted for clinical application.
Keywords:
Immune cellsImmune homeostasisImmunotherapyN6-methyladenosine (m6A)Tumor microenvironment

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