Related Experiment Video
Updated: Jul 25, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Stimulus-Responsive Zwitterionic Prodrug Delivery System with Sustained Release of Hydrogen Sulfide for Protective
Bibo Ren1,2, Ruiqi Liu3, Qian He4
1Department of Cardiovascular surgery, West China Hospital, Sichuan University, Chengdu 610065, P. R. China.
Abstract:
Aortic dissection (AD) is one of the most frequent types of aortic disease with extremely poor prognosis. The biological signaling gas hydrogen sulfide (H2S) has exhibited protective effects in various types of cardiovascular diseases. However, as a toxic, colorless gas, the application of H2S is immensely hampered due to the lack of ideal donors. In this article, a drug delivery system with a H2S donor has been prepared. Meanwhile, the donor could be deposed in a cysteine-containing environment to generate H2S. The results indicate that the H2S donor polymer nanomicelles mitigated the processive transformation of smooth muscle cells effectively in a proper concentration range, which may play a protective role in aortic dissection. In animal experiments, the sustained-release H2S donor stimulated in the presence of cysteine was found to demonstrate beneficial effects in a murine model of aortic dissection and would likely become a potential target of H2S therapy for cardiovascular diseases.
More Related Videos
Related Concept Videos
Modified-Release Drug Delivery Systems: Rate-Programmed I
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Site-Targeted
Oral Drug Delivery Systems: Continuous-Release Systems
Oral Drug Delivery Systems: Delayed-Release Systems
Transdermal Drug Delivery Systems

