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Study on the correlation between B vitamins and breast cancer
Siqi Xie1, Mingjian Tan1, Hongwan Li1
1Department of Breast Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People's Republic of China.
Cancer Cell International
|February 10, 2023
Summary
Serum B vitamin levels may influence breast cancer risk. Higher Vitamin B1 and B5 levels were found in patients, while lower Vitamin B3 levels were observed in breast cancer patients, suggesting a complex relationship.
Area of Science:
- Biochemistry
- Oncology
- Nutritional Science
Background:
- Serum vitamin levels are linked to breast cancer risk, but findings are inconsistent.
- Diet and supplementation impact vitamin levels, suggesting potential for risk reduction.
- The relationship between serum vitamins and breast cancer remains controversial.
Purpose of the Study:
- To compare serum vitamin levels in healthy individuals, benign breast disease patients, and breast cancer patients.
- To evaluate the association between B vitamin levels and breast cancer risk.
Main Methods:
- Serum vitamin levels were measured using liquid chromatography-tandem mass spectrometry in 520 individuals.
- Included 91 healthy controls, 38 benign breast disease patients, and 87 breast cancer patients.
- Statistical analyses included Kruskal-Wallis H test, Chi-squared test, and binary logistic regression.
Main Results:
- Serum Vitamin B1 and Vitamin B5 levels were elevated in breast cancer and benign breast disease patients compared to controls.
- Serum Vitamin B3 levels were lower in breast cancer patients than in controls and benign breast disease patients.
- Vitamin B1 showed a positive correlation with breast cancer risk, while Vitamin B3 showed a negative correlation.
Conclusions:
- Vitamin B1 and B3 levels are significantly associated with breast cancer risk.
- Vitamin B5 levels did not show a significant relationship with breast cancer risk.
- These findings highlight the differential roles of specific B vitamins in breast cancer etiology.
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