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Perspective insights into hydrogels and nanomaterials for ischemic stroke
Qingbo Yu1,2, Zhang Jian3, Dan Yang2
1Laboratory of Anesthesia & Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, China.
Frontiers in Cellular Neuroscience
|February 10, 2023
Summary
New biomaterials offer promising therapeutic potential for ischemic stroke (IS) treatment, overcoming limitations of current therapies. This review explores advances in hydrogels and nanomaterials for improved drug delivery and patient outcomes.
Area of Science:
- Biomaterials Science
- Neurology
- Regenerative Medicine
Background:
- Ischemic stroke (IS) is a leading cause of global disability and mortality.
- Current treatments like tissue plasminogen activator (tPA) and thrombectomy have narrow therapeutic windows.
- Preclinical findings for IS lack translatability, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review recent advances in biomaterials for ischemic stroke treatment.
- To discuss the therapeutic potential of novel biomaterials from research to clinical application.
- To highlight the convergence of material science and medicine for IS therapy.
Main Methods:
- Literature review of biomaterial applications in ischemic stroke.
- Analysis of hydrogels and nanomaterials for drug delivery and scaffolding.
- Evaluation of biomaterial properties like brain-targeting, biocompatibility, and functionality.
Main Results:
- Biomaterials offer versatile applications as structural scaffolds or drug delivery vehicles.
- Biomaterial-mediated drug delivery enhances therapeutic effects through targeted action.
- Emerging biomaterials show significant potential for improving IS treatment outcomes.
Conclusions:
- Novel biomaterials represent a promising frontier in ischemic stroke therapy.
- Biomaterial-based approaches can overcome limitations of existing IS treatments.
- The integration of material science and medicine is crucial for future IS therapeutic development.
