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Chemerin levels in chronic kidney disease: A systematic review and meta-analysis

Amir Hossein Behnoush1,2, Parnian Shobeiri1,2,3,4, Pegah Bahiraie5

  • 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Frontiers in Endocrinology
|February 10, 2023
PubMed

Insights

This study found elevated chemerin levels in chronic kidney disease (CKD) patients, suggesting its potential as an inflammatory biomarker. Further research is needed to explore chemerin

Area of Science:

  • Biochemistry
  • Nephrology
  • Immunology

Background:

  • Chemerin is recognized for its role as an inflammatory biomarker.
  • Chronic kidney disease (CKD) is a significant global health concern associated with high mortality and morbidity.
  • Previous studies have explored chemerin levels in CKD patients, necessitating a comprehensive review.

Purpose of the Study:

  • To systematically review and meta-analyze the association between chemerin levels and chronic kidney disease.
  • To investigate chemerin as a potential biomarker in various stages of CKD, including end-stage renal disease.

Main Methods:

  • A systematic search was conducted across PubMed, Scopus, Embase, and Web of Science databases.
  • Studies comparing chemerin levels in CKD patients (including hemodialysis patients) with healthy controls were included.
  • Random effects meta-analysis was employed to calculate the standardized mean difference (SMD) and 95% confidence intervals (CI).

Main Results:

  • Eight studies involving 875 participants were analyzed, all demonstrating high quality.
  • Meta-analysis revealed significantly higher chemerin levels in CKD patients compared to healthy controls (SMD 2.15, 95% CI 0.83-3.48, p<0.01).
  • Hemodialysis patients also exhibited statistically higher chemerin levels than controls (SMD 2.10, 95% CI 0.58-3.62, p=0.01).

Conclusions:

  • Chemerin shows potential as a valuable biomarker for CKD, indicating underlying inflammatory pathways.
  • Further investigation is warranted to elucidate the clinical applications and pathophysiological role of chemerin in CKD.
Abstract

Keywords:
chemerinchronic kidney diseasemeta-analysisrenal diseasesystematic review

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