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Application of sequential multimodal analgesia before and after impacted mandibular third molar extraction: Protocol
Soo-Ho Kim1, Somi Kim2, Yoon-Seon Kim2
1Department of Dentistry, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon, 35015, South Korea.
Contemporary Clinical Trials Communications
|February 10, 2023
Summary
This study evaluates a new pain management protocol for impacted mandibular third molar extraction. It combines preemptive analgesics with postoperative zaltoprofen to improve pain control and reduce side effects.
Area of Science:
- Oral surgery
- Anesthesiology
- Pharmacology
Background:
- Postoperative pain following impacted mandibular third molar extraction is often moderate to severe.
- Current analgesic protocols lack consensus on optimal pain management and side effect minimization.
Purpose of the Study:
- To evaluate the efficacy and safety of sequential multimodal analgesia combined with postoperative zaltoprofen and preemptive analgesics.
- To provide evidence for a novel pain management protocol in oral surgery.
Main Methods:
- Multi-center, prospective, double-blind, randomized controlled trial with a crossover design.
- 80 participants with bilateral impacted mandibular third molars underwent extractions at one-month intervals.
- Preemptive analgesics (celecoxib or tramadol/acetaminophen) or placebo were administered before extraction, followed by zaltoprofen for 5 days post-extraction.
Main Results:
- The study is ongoing and designed to collect data on pain levels, onset time, rescue medication needs, and side effects.
- Specific results are pending the completion of the clinical trial.
Conclusions:
- The trial aims to establish effective postoperative pain management strategies for oral surgeries.
- Results will guide clinicians on the optimal timing and combination of oral analgesics.
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