Related Experiment Video

Updated: Aug 10, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.8K

The effect of serum uric acid concentration on the severity of chronic congestive heart failure

Ali Hasan Ismaeel Alshamari1, Rossal Kamil Kadhim2, Sadiq Jebar Ali Al-Mohana1

  • 1Department of Medicine, College of Medicine, Kufa University, Kufa, Iraq.

Journal of Medicine and Life
|February 10, 2023
PubMed

Insights

High serum uric acid levels negatively impact chronic congestive heart failure severity. This finding highlights a direct link between elevated uric acid and poorer heart failure outcomes, including reduced left ventricular ejection fraction.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Chronic congestive heart failure (CHF) is a significant global health concern.
  • Serum uric acid is increasingly recognized as a potential biomarker in cardiovascular diseases.

Purpose of the Study:

  • To investigate the adverse effects of serum uric acid concentration on the severity of chronic congestive heart failure.
  • To explore the relationship between high serum uric acid and indicators of CHF severity.

Main Methods:

  • A cohort of 100 patients with CHF (including those with hypertension, smoking, and diabetes mellitus) was studied.
  • Data collection involved detailed medical history and clinical examinations.
  • Serum uric acid levels were analyzed in relation to CHF classification (NYHA III and IV) and left ventricular ejection fraction.

Main Results:

  • Increased serum uric acid concentration demonstrated a direct negative effect on CHF severity and hypertension.
  • High serum uric acid was significantly associated with advanced CHF classes (NYHA III and IV).
  • Elevated uric acid levels correlated with a decrement in left ventricular ejection fraction.

Conclusions:

  • Serum uric acid concentration is a critical factor influencing the severity of chronic congestive heart failure.
  • Elevated uric acid levels are linked to poorer cardiac function and advanced disease stages in CHF patients.
  • Monitoring serum uric acid may aid in assessing CHF prognosis and guiding treatment strategies.

Keywords:
chronic congestive heart failureserum uric aciduric acid concentration

More Related Videos

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

163

Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
440
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
480
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
19
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
21
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
131
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
20