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Updated: Aug 10, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
Published on: January 5, 2024
SPTing across condensates: SEC-mediated translocation of SPT complex from pausing condensates to elongation
Prashant Rawat1, Ritwick Sawarkar2
1Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
Abstract:
Several independent studies in the last few years have suggested that phase separation and biomolecular condensation play a critical role in regulating different transcription steps from initiation to pausing and elongation. However, how components of the transcription machinery translocate among different types of condensates during transcription remains poorly understood. Guo et al have now identified a potential mechanism underlying translocation of the DSIF complex from pausing to elongation condensates during promoter pause release, as reported in this issue of EMBO reports.
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