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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Related Experiment Video

Updated: Aug 10, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Coronavirus Immunotherapeutic Consortium Database.

Jarjapu Mahita1, Brendan Ha1, Anais Gambiez1

  • 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

Database : the Journal of Biological Databases and Curation
|February 10, 2023
PubMed
Summary
This summary is machine-generated.

The Coronavirus Immunotherapeutic Consortium (COVIC) created a database of SARS-CoV-2 antibodies. COVIC-DB standardizes antibody data for better analysis and therapeutic development.

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Area of Science:

  • Immunology
  • Virology
  • Bioinformatics

Background:

  • The COVID-19 pandemic spurred the development of numerous SARS-CoV-2 antibodies.
  • Inconsistent experimental conditions hinder the comparison of antibody efficacy.
  • A standardized resource is needed to consolidate and analyze antibody data.

Purpose of the Study:

  • To establish a centralized, publicly accessible database of anti-SARS-CoV-2 antibody functional properties.
  • To enable consistent, side-by-side comparison of antibody characteristics.
  • To facilitate the interpretation of large-scale antibody datasets.

Main Methods:

  • The Coronavirus Immunotherapeutic Consortium (COVIC) conducted standardized, blinded, side-by-side testing of antibodies.
  • A comprehensive database (COVIC-DB) was developed to store and present experimental data.
  • Interactive tools were implemented for data visualization and analysis.

Main Results:

  • COVIC-DB provides a unified view of antibody features including affinity, neutralization, in vivo protection, and effector functions.
  • The database enables systematic analysis and interpretation of antibody data.
  • Interactive graphs allow direct comparison of antibodies based on functional properties.

Conclusions:

  • COVIC-DB offers a valuable resource for researchers studying SARS-CoV-2 antibodies.
  • The database can guide the development of effective therapeutic antibody cocktails.
  • Standardized data facilitates a deeper understanding of antibody-mediated immunity against SARS-CoV-2.