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Published on: May 14, 2013
IgG4 related disease and aortitis: an up-to-date review
N Jayachamarajapura Onkaramurthy1, S C Suresh2, P Theetha Kariyanna3
1Department of Internal Medicine, NYC Health and Hospitals/Harlem Hospital Center, New York, NY, USA.
Abstract:
Aortic involvement in immunoglobulin G4-related disease (IgG4-RD) is extremely rare and is often overlooked during the aortitis work-up. IgG4-related aortitis differs from non-IgG4-related aortitis in its histopathological features, site of involvement, laboratory markers, and treatment options. The histopathological examination of the vessel walls characteristically reveals adventitial thickening with intimal sparing, typically affecting the infrarenal abdominal aorta. In addition, inadequate knowledge about the disease often leads to delayed or missed diagnosis and undermanagement of a potentially treatable condition. Hence, in this paper, we review the unique clinical manifestations, laboratory markers, diagnostic features, current treatment strategies, and novel experimental therapeutic options in the management of IgG4-related aortitis.
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