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Published on: June 25, 2015
Photo- and Tetrazine-Responsive Modulation of trans-Zeatin
Xin Sun1,2, Li Liu1,2, Liang Cheng1,2
1Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Abstract:
Photoirradiation and small organic molecule triggering of appropriately designed caged hormones enable the control and manipulation of the corresponding biological processes with high spatial and temporal resolution. Caged trans-zeatin substituted with nitrobenzene carbonates as photoremovable protecting groups and trans-cyclooctene as the tetrazine-responsive motif have been synthesized. A smooth release of the trapped trans-zeatin molecule has been achieved, permitting targeted perturbation of biological processes, including degradation, glucosylation, and recognition by appropriate enzymes.
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