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High-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritis

Thao H P Nguyen1,2,3, Morten Wang Fagerland4, Ivana Hollan5,6

  • 1Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway.

Plos One
|February 10, 2023
PubMed

Insights

High-sensitivity cardiac troponin T (hsTnT) correlates with inflammatory arthritis disease activity. However, hsTnT levels did not change with antirheumatic treatments, unlike other inflammatory markers.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Inflammatory arthritis (IA) involves systemic inflammation.
  • Cardiac involvement in IA is a concern.
  • High-sensitivity cardiac troponin T (hsTnT) is a biomarker for cardiac injury.

Purpose of the Study:

  • To determine if hsTnT correlates with disease activity in IA.
  • To investigate the effect of antirheumatic treatments on hsTnT levels.

Main Methods:

  • 115 patients with active IA (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis) were assessed.
  • hsTnT and clinical/laboratory markers were measured at baseline and after 6 weeks/6 months.
  • Patients received methotrexate (MTX) or tumor necrosis factor inhibitor (TNFi) ± MTX.

Main Results:

  • Baseline hsTnT positively correlated with disease activity scores and inflammatory markers in IA patients, particularly in rheumatoid arthritis.
  • hsTnT levels showed a median of 5.0 ng/L at baseline.
  • No significant changes in hsTnT levels were observed at 6 weeks or 6 months despite antirheumatic therapy.

Conclusions:

  • hsTnT is associated with disease activity in inflammatory arthritis.
  • Antirheumatic treatments did not significantly alter hsTnT levels over 6 months.
  • hsTnT may not be a dynamic marker for treatment response in IA.
Abstract

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