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Related Experiment Videos

Tympanic epithelial migration.

D Boedts

    Clinical Otolaryngology and Allied Sciences
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Tympanic epidermal migration is slow, originating in the basal cell layer near the annulus tympanicus. This differs from rapid keratin removal, which may explain ear grommet displacement.

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    Area of Science:

    • Otolaryngology
    • Dermatology
    • Cell Biology

    Background:

    • Tympanic epidermal migration is a poorly understood process.
    • Existing literature suggests rapid epithelial migration on the tympanic membrane.
    • The role of this migration in physiological processes and device extrusion is unclear.

    Purpose of the Study:

    • To review the literature on tympanic epidermal migration.
    • To investigate the location and rate of tympanic mitotic activity and cell migration.
    • To differentiate between slow and rapid epithelial migration on the tympanic membrane.

    Main Methods:

    • Literature review.
    • Isotope experiments.
    • Whole-mount autoradiographs.

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    Main Results:

    • Tympanic mitotic activity is localized near the annulus tympanicus.
    • A slow migratory activity of labeled cells was observed in the basal cell layer.
    • Perforation of the tympanic membrane did not affect label position.
    • A rapid epithelial migration, distinct from the observed slow migration, is proposed to occur in the stratum corneum.

    Conclusions:

    • Tympanic epidermal migration is a slow process originating in the basal cell layer.
    • Rapid epithelial migration in the stratum corneum may be responsible for keratin removal.
    • This rapid migration may contribute to the extrusion and displacement of ear grommets.