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Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials.

P Hou1, M O Besenhard2, G Halbert1

  • 1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G1 1XQ, UK; Centre for Continuous Manufacturing and Advanced Crystallisation (CMAC), University of Strathclyde, Glasgow G1 1RD, UK.

International Journal of Pharmaceutics
|February 10, 2023
PubMed
Summary
This summary is machine-generated.

A novel pneumatic micro-feeder achieves consistent powder micro-feeding (<0.7 g/h) for pharmaceutical manufacturing. This advanced design minimizes flow rate variations, even for cohesive active pharmaceutical ingredients (APIs) and excipients.

Keywords:
Continuous feedingHigh accuracyMicro-feedingPneumatic transferringPowder feeding

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Area of Science:

  • Pharmaceutical Manufacturing
  • Powder Technology
  • Process Engineering

Background:

  • Consistent powder micro-feeding (<100 g/h) is crucial for solid oral dosage forms, enhancing drug efficacy and reducing waste.
  • Existing micro-feeders struggle with low flow rates (<20 g/h) and cohesive pharmaceutical powders.
  • Challenges include content consistency and minimizing fluctuations for active pharmaceutical ingredients (APIs) and excipients.

Purpose of the Study:

  • To present an advanced micro-feeder design for consistent powder feeding at low flow rates.
  • To overcome limitations of current micro-feeders with cohesive pharmaceutical powders.
  • To achieve flow rates as low as 0.7 g/h with less than 20% flow rate variation.

Main Methods:

  • A novel pneumatic micro-feeder utilizing particle re-entrainment for powder conveying.
  • Investigated process parameters: air pressure, air flow rate.
  • Examined equipment configurations: insert size, plug position.
  • Tested pharmaceutical-grade powders: microcrystalline cellulose (MCC), croscarmellose sodium (CCS), crospovidone (XPVP), and paracetamol (APAP).

Main Results:

  • The micro-feeder successfully achieved consistent powder flow rates as low as 0.7 g/h.
  • Demonstrated low flow rate variation (<20%) even with cohesive powders.
  • Showcased good repeatability and stability in powder feeding.
  • Identified optimal process parameters and equipment configurations for different powders.

Conclusions:

  • The developed pneumatic micro-feeder offers excellent performance for micro-feeding pharmaceutical powders, including cohesive ones.
  • The particle re-entrainment concept effectively minimizes flow rate variations.
  • This technology addresses a significant gap in pharmaceutical manufacturing for precise low-dose powder delivery.