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Updated: Aug 12, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
[Effect of hemodynamic disorders on the transepithelial potential of the rat liver in vivo]
Abstract:
The presence of transepithelial electrical potential (TEP) formed on the border between the interstitium and the interior of the rat liver bile capillary has been demonstrated. The initial TEP value (II+ 3 mV) reduced rapidly to zero after the ligation of different portal fissure vessels, while ischemia arrest led to TEP restoration. True periodical oscillations of TEP value with the period and amplitude of about 30 s and 1-2 mV, respectively, were registered. These oscillations appeared in all cases of liver ischemia 5-7 min after ischemia removal and lingered till the end of the experiment. It was assumed that variations in TEP and membrane potential of hepatocytes have the common nature.
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