Related Experiment Video

Updated: Aug 10, 2025

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
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Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in

Kelvin Wei Zhern Loh1,2, Zhenyu Hu1,2, Tuck Wah Soong3,4,5

  • 1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Handbook of Experimental Pharmacology
|February 10, 2023
PubMed

Insights

Emerging proteins like Galectin-1 and Cereblon fine-tune CaV1.2 calcium channel activity, offering new therapeutic targets for cardiovascular diseases, including those linked to SARS-CoV-2 infection.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Pharmacology

Background:

  • The CaV1.2 calcium channel is crucial for cardiac and smooth muscle function.
  • Dysregulation of CaV1.2 contributes to cardiovascular diseases like hypertension and heart failure.

Purpose of the Study:

  • To explore novel CaV1.2 interacting proteins for therapeutic development.
  • To investigate the roles of Galectin-1 and Cereblon in cardiovascular disease.
  • To assess CaV1.2 channel involvement in SARS-CoV-2 infection and related cardiovascular symptoms.

Main Methods:

  • Literature review and analysis of emerging research on CaV1.2 channel modulators.
  • Discussion of protein-protein interactions involving CaV1.2.
  • Evaluation of clinical implications for cardiovascular conditions.

Main Results:

  • Galectin-1 and Cereblon emerge as key regulators of CaV1.2 channel activity.
  • These interactions influence pathways relevant to hypertension and heart failure.
  • CaV1.2 channel activity is implicated in SARS-CoV-2 pathogenesis and associated cardiovascular issues.

Conclusions:

  • Modulating CaV1.2 channel activity via novel interacting proteins presents a promising therapeutic strategy.
  • Understanding these interactions can lead to improved treatments for cardiovascular diseases, including COVID-19 complications.

Keywords:
COVID-19CaV1.2 channelGalectinHeart failureHypertension

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