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Updated: Aug 10, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

The Same-Up-Down Staging System for Recurrent Early Glottic Cancer.

Giuseppe Licci¹, Luca Giovanni Locatello², Giandomenico Maggiore¹

¹Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.

|February 11, 2023

Summary

A new staging system, Same-Up-Down (SUD), effectively predicts survival outcomes for patients with recurrent early glottic cancer (rEGC). This system improves prognostic accuracy compared to existing methods for rEGC patients.

Keywords:

glottic cancer laryngeal cancer recurrence squamous-cell carcinoma staging

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Area of Science:

Otolaryngology
Oncology
Medical Staging Systems

Background:

Recurrent early glottic cancer (rEGC) presents significant treatment challenges.
Accurate prognostication is crucial for managing rEGC patients.

Purpose of the Study:

To evaluate the prognostic performance of the novel Same-Up-Down (SUD) staging system for rEGC.
To compare the SUD system against established staging methods (rTNM, CLRSS, CLRSS-2).

Main Methods:

Retrospective analysis of 258 rEGC patients.
Assessment of staging systems using univariate and multivariate Cox analysis.
Comparison of predictive capabilities via Harrell's C-index.

Main Results:

The SUD system demonstrated significant predictive power for overall survival (p=0.022) and second-recurrence-free survival (p=0.024).
SUD outperformed rTNM, CLRSS, and CLRSS-2 in predicting survival outcomes.
Improvements in predictive capacity for overall survival, disease-specific survival, and second-recurrence-free survival were observed.

Conclusions:

The SUD staging system offers efficient survival prediction for rEGC patients.
Prognosis in rEGC is strongly influenced by both initial and recurrent locoregional disease extent.