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An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis

Huan Yan1,2,3, Jing-Ling Zhang1,2,3, Kam-Tong Leung4

  • 1Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Sir Y.K. Pao Cancer Center, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, China.

Cancers
|February 11, 2023
PubMed

Insights

G-protein-coupled receptors (GPCRs) are vital for cell signaling and tissue balance. Aberrant GPCR signaling drives gastric cancer (GC) progression, offering new diagnostic and therapeutic targets for this malignancy.

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • G-protein-coupled receptors (GPCRs) are a superfamily of cell surface receptors that mediate cellular responses to external stimuli.
  • GPCR signaling pathways are essential for maintaining tissue homeostasis.
  • Genetic aberrations in GPCRs and G proteins are implicated in various cancers.

Purpose of the Study:

  • To review the role and mechanisms of GPCRs in gastric cancer (GC).
  • To highlight GPCRs as potential biomarkers and therapeutic targets in GC.
  • To discuss novel strategies for targeting GPCRs to combat GC.

Main Methods:

  • Literature review of research on GPCRs and G proteins in malignancies.
  • Analysis of high-throughput sequencing data identifying GPCR aberrations.
  • Investigation of GPCR signaling pathways in GC initiation and development.

Main Results:

  • Altered GPCRs and G proteins can serve as biomarkers for GC diagnosis and prognosis.
  • Dysregulated GPCR signaling contributes to GC cell proliferation, metastasis, and immune evasion.
  • Aberrant GPCR activation remodels the tumor microenvironment.

Conclusions:

  • GPCRs play a significant role in gastric cancer pathogenesis.
  • Targeting GPCR activation presents a promising therapeutic strategy for GC.
  • Eliminating GPCR-driven gastric carcinogenesis is a key goal for future research.
Keywords:
G proteinG-protein-coupled receptorgastric cancertargeted therapy

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