Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

506
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
506

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Constrained acetabular liner total hip arthroplasty versus conventional hemiarthroplasty for unstable comminuted femoral intertrochanteric fractures in elderly patients with neurological disorders.

BMC surgery·2026
Same author

SPOTTER: Automated Tissue-Barcoding Platform for Spatial Proteomics and Phosphoproteomics.

bioRxiv : the preprint server for biology·2026
Same author

Characterizing the Effects of Protein Glycosylation Perturbation on Phosphorylation Signaling.

Analytical chemistry·2026
Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026
Same author

Proteomic Identification of Pig Xenoantigens for Clinical Xenotransplantation.

bioRxiv : the preprint server for biology·2026
Same author

A Biomarker Panel for the Detection of Pancreatic Cancer.

Cancers·2026

Related Experiment Video

Updated: Aug 10, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

325

Urinary PSA and Serum PSA for Aggressive Prostate Cancer Detection.

Naseruddin Höti1,2, Tung-Shing Lih1, Mingming Dong1

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Cancers
|February 11, 2023
PubMed
Summary

Urinary prostate-specific antigen (PSA) levels may help detect aggressive prostate cancer better than serum PSA. Combining urine and serum PSA tests improves diagnostic accuracy for aggressive disease.

Keywords:
prostate cancerprostate specific antigenurine

More Related Videos

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
06:23

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

14.9K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K

Related Experiment Videos

Last Updated: Aug 10, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

325
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
06:23

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

14.9K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K

Area of Science:

  • Urology
  • Oncology
  • Biomarker Discovery

Background:

  • Serum prostate-specific antigen (PSA) and digital rectal examination are standard for prostate cancer management.
  • Limitations exist in serum PSA's ability to identify aggressive prostate cancer.

Purpose of the Study:

  • To evaluate the clinical utility of urinary PSA levels for prostate cancer diagnosis.
  • To compare the diagnostic performance of urinary PSA versus serum PSA in detecting aggressive prostate cancer.

Main Methods:

  • Analyzed 437 urine specimens from prostate cancer patients using the Access Hybritech PSA assay.
  • Validated findings with immunohistochemistry (IHC) on tumor tissues and metastatic lesions.
  • Assessed predictive power using Area Under the Curve (AUC) analysis for urinary PSA, serum PSA, and their ratio.

Main Results:

  • Aggressive prostate cancer cases showed lower urinary PSA and higher serum PSA levels.
  • Urinary PSA demonstrated higher predictive power (AUC=0.732) for aggressive disease compared to serum PSA.
  • Combining serum and urine PSA assays, along with their ratio, further enhanced prediction (AUC=0.811).

Conclusions:

  • Urinary PSA may serve as a better indicator of aggressive prostate cancer than serum PSA.
  • The combination of serum and urine PSA assays offers improved detection of aggressive prostate cancer.