Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malignant Transformation in Oral Lichen Planus and Oral Lichenoid Lesions: A Retrospective Study.

Head & neck·2026
Same author

Prognostic factors for tracheostomy in patients with cervicofacial cellulitis.

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer.

Nature·2026
Same author

Optimizing care for patients with maxillomandibular Gorham-Stout disease.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same author

Correction: Anatomical study of the vascularization of the pedicled osteo-myo-cutaneous scapulo-dorsal flap.

Surgical and radiologic anatomy : SRA·2026
Same author

Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Related Experiment Video

Updated: Aug 10, 2025

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.1K

Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming.

Guillaume Collin1, Jean-Philippe Foy1, Nicolas Aznar1

  • 1Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Université Lyon1, 69008 Lyon, France.

Cancers
|February 11, 2023
PubMed
Summary

Inflammatory bowel disease involves reactive oxygen species (ROS). This study shows intestinal cells adapt to ROS via genetic reprogramming, potentially increasing cancer risk in Crohn's and ulcerative colitis patients.

Keywords:
ZEB transcription factorsadaptation to chronic-inflammation-associated oxidative stressinflammatory bowel disease progressionintestinal cell reprogramming

More Related Videos

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.6K
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.7K

Related Experiment Videos

Last Updated: Aug 10, 2025

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.1K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.6K
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.7K

Area of Science:

  • Cell biology
  • Gastroenterology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are implicated as key drivers in inflammatory bowel diseases (IBD).
  • Intestinal stem cells may develop adaptive strategies to counteract ROS-induced damage.
  • This adaptation could enhance tolerance to oncogenic insults, promoting neoplastic transformation.

Purpose of the Study:

  • To investigate adaptive strategies of intestinal stem cells to chronic oxidative stress.
  • To explore the link between ROS adaptation, IBD progression, and colorectal cancer initiation.
  • To identify genetic reprogramming associated with oxidative stress in intestinal epithelial cells.

Main Methods:

  • Immortalized human colonic epithelial cells were exposed to chronic inflammation mimics or chemical peroxide.
  • Gene set enrichment analysis was used to identify adaptive programs.
  • Database analysis and murine models were employed to assess biological relevance in IBD and colorectal cancer.

Main Results:

  • Cells adapted to oxidative stress through partial genetic reprogramming.
  • This reprogramming program is active in Crohn's disease and ulcerative colitis patient mucosa and progresses with disease.
  • The adaptive program was confirmed in intestinal precursor cells during murine colorectal cancer development.

Conclusions:

  • Cellular adaptation to oxidative stress in IBD involves genetic reprogramming.
  • This adaptive process may contribute to IBD progression and colorectal cancer initiation.
  • Understanding this mechanism offers insights into IBD pathogenesis and cancer development.