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Molecular Biomarkers in Perthes Disease: A Review
Vesna Spasovski1, Sanja Srzentić Dražilov1, Gordana Nikčević1
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, Serbia.
Diagnostics (Basel, Switzerland)
|February 11, 2023
Summary
Understanding the biological factors in Perthes disease (juvenile osteonecrosis of the femoral head) is key. Research highlights genetic and molecular targets for earlier diagnosis and improved treatment of this childhood condition.
Area of Science:
- Orthopedics
- Pediatric Osteology
- Molecular Biology
Background:
- Perthes disease is a childhood condition involving osteonecrosis of the femoral head.
- Etiology and factors influencing disease severity are increasingly understood.
- Affects children under 15, impacting bone remodeling.
Purpose of the Study:
- To review biological factors in Perthes disease pathogenesis.
- To assess diagnostic, clinical, and therapeutic significance of these factors.
- To focus on candidate genes and clinical severity indicators.
Main Methods:
- Systematic literature review of 68 articles from PubMed.
- Inclusion criteria: studies with clinical or preclinical results.
- Focused on genetic susceptibility and clinical severity factors.
Main Results:
- Summarized findings on vascular involvement and inflammatory molecules.
- Identified factors contributing to impaired bone remodeling.
- Suggested candidate genes as potential therapeutic targets.
Conclusions:
- Molecular biomarkers are crucial for early and accurate Perthes disease diagnosis.
- Biomarkers enable precise follow-up and early-phase treatment.
- Advances in understanding biological factors can improve patient outcomes.
