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Atherosclerosis, Cardiovascular Disorders and COVID-19: Comorbid Pathogenesis
Yulia A Makarova1, Varvara A Ryabkova1,2, Vladimir V Salukhov3
1Laboratory of the Microangiopathic Mechanisms of Atherogenesis, Saint Petersburg State University, 199034 Saint-Petersburg, Russia.
Diagnostics (Basel, Switzerland)
|February 11, 2023
Summary
Atherosclerosis and COVID-19 have a bidirectional relationship, where cardiovascular disease impacts viral susceptibility and SARS-CoV-2 exacerbates atherosclerosis. This interaction affects vascular, cellular, and molecular pathways, influencing disease severity and plaque stability.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Pathogenesis
Background:
- Atherosclerosis and coronavirus disease 19 (COVID-19) are significant global health concerns.
- Understanding their comorbid pathogenesis is crucial for patient management.
Purpose of the Study:
- To elucidate the bidirectional relationship between atherosclerosis and COVID-19.
- To explore the vascular, cellular, and molecular mechanisms underlying their interaction.
Main Methods:
- Review of current scientific literature on atherosclerosis and COVID-19.
- Analysis of pathogenic pathways at multiple biological levels.
Main Results:
- Cardiovascular disease influences susceptibility to SARS-CoV-2 infection.
- SARS-CoV-2 negatively impacts endothelium and cardiomyocytes, promoting thrombosis and inflammation.
- COVID-19 can trigger atherosclerosis plaque instability and affect large vessels via vasa vasorum.
Conclusions:
- The interplay between atherosclerosis and COVID-19 involves complex molecular and cellular mechanisms.
- SARS-CoV-2 infection can accelerate atherosclerosis progression and complications.
- Further research is needed on therapeutic interactions and novel viral entry pathways.
Keywords:
COVID-19atheromaatherosclerosisautoimmunitycardiovascular systemcytokinesendotheliuminflammationlipoproteinsrenin-angiotensin systemvasa vasorumMore Related Videos
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